Alcohols and polyols
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- (464)
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- (11)
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- (145)
- (116)
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- (1)
- (1)
- (1)
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Filtered Search Results
Medchemexpress LLC Aprindine hydrochloride | 33237-74-0 | 99.0% | C22H31ClN2 | 50 MG
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Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. It primarily blocks sodium channels (INa) and significantly inhibits delayed potassium currents, helping to prolong the atrial effective refractory period (AERP) and prevent atrial fibrillation. It also regulates intracellular calcium ion concentration by inhibiting the Na+/Ca2+ exchange current (INCX), further stabilizing cardiac electrical activity. It is used in the study of atrial fibrillation (AF) and ventricular arrhythmias.
- Functions as an Ib-class anti-arrhythmic agent.
- Blocks sodium channels (INa) and inhibits delayed potassium currents.
- Regulates intracellular calcium ion concentration by inhibiting Na+/Ca2+ exchange current (INCX).
- Used for studying atrial fibrillation (AF) and ventricular arrhythmias.
- Inhibits proliferation of bone marrow cells and human lymphocytes.
- Demonstrates anti-arrhythmic effects in vivo.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Fedratinib (hydrochloride hydrate) | 1374744-69-0 | MFCD28137677 | 99.9% | 615.62 g/mol | C27H40Cl2N6O4S | 2 G
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Fedratinib hydrochloride hydrate is the dihydrochloride monohydrate salt of fedratinib, an ATP-competitive, orally active and selective JAK2 inhibitor supplied for research use. The compound is provided as a solid (white to yellow) with high reported purity and is intended for in vitro and preclinical studies; not for human therapeutic use.
- High purity (≈99.9%) as reported by supplier.
- Molecular weight 615.62 g/mol; formula C27H40Cl2N6O4S.
- Packaged in small-scale quantities, commonly available as 2 G.
- Recommended storage: solid at 4°C; in solution -20°C to -80°C.
- Potent JAK2 inhibitor with reported IC50 ≈3 nM, suitable for signaling and oncology research.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Ribociclib hydrochloride | 1211443-80-9 | >99.9% | 471.00 | 10 MG
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Ribociclib hydrochloride is an ATP-competitive and orally active CDK4/6 inhibitor designed for research use. It effectively crosses the blood-brain barrier and demonstrates potent inhibitory activity against CDK4 and CDK6.
- ATP-competitive and orally active CDK4/6 inhibitor
- Crosses the blood-brain barrier
- IC50 values of 10 nM for CDK4 and 39 nM for CDK6
- Over 1,000-fold less potent against the cyclin B/CDK1 complex
- Induces cell-cycle arrest in G0/G1 phase
- Significantly delays tumor growth in neuroblastoma xenografts
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Medchemexpress LLC CCG258208 hydrochloride | 98.1% | 488.94 | 1 MG
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CCG258208 (GRK2-IN-1) hydrochloride is a potent and selective GRK2 (G protein-coupled receptor kinase 2) inhibitor (IC50=30 nM). It exhibits 230-fold selectivity over GRK5 and more than 2500-fold selectivity over GRK1, PKA, and ROCK1. This compound can be utilized in heart failure research.
- Potent and selective GRK2 inhibitor (IC50=30 nM).
- Exhibits 230-fold selectivity over GRK5 (IC50=7.09 μM) and more than 2500-fold selectivity over GRK1 (IC50=87.3 μM), PKA, and ROCK1.
- Applicable in heart failure research.
- Significant improvement in βAR-stimulated contractility in mouse cardiomyocytes at concentrations as low as 0.1 μM.
- Superior half-life in vivo with total plasma drug levels exceeding the GRK2 IC50 for seven hours after a single intraperitoneal administration of 10 mg/kg in CD-1 mice.
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Medchemexpress LLC Olprinone hydrochloride | 119615-63-3 | 99.9% | C14H11ClN4O | 50 MG
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Olprinone Hydrochloride is a potent phosphodiesterase (PDE) 3 inhibitor, showing IC50s of 0.35 μM for PDE3. It is utilized in research for heart failure due to its positive inotropic and vasodilative effects, and also demonstrates anti-inflammatory activity.
- Potent PDE3 inhibitor
- Used in research for heart failure
- Exhibits positive inotropic and vasodilative effects
- Demonstrates anti-inflammatory activity
- Modulates inflammation associated with myocardial ischemia-reperfusion injury
- Reduces pro-inflammatory cytokines such as TNF-α and IL-1β
- Decreases expression of adhesion molecules like ICAM-1 and P-Selectin
- Inhibits apoptosis related to myocardial injury
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Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | 99.5% | 576.13 g·mol⁻¹ | C28H42ClN7O4 | 10 MG
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EPZ004777 hydrochloride is a potent, selective inhibitor of the histone methyltransferase DOT1L used in epigenetic and leukemia research. It inhibits DOT1L with an IC50 of 0.4 nM, reduces H3K79 methylation in cells, and has been used to selectively kill MLL-rearranged leukemia cells. This material is supplied for research use only.
- Potent DOT1L inhibition (IC50 0.4 nM).
- Selective activity in biochemical and cellular assays.
- Reduces H3K79 methylation and downregulates leukemogenic gene expression.
- High chemical purity (99.5%).
- Available as solid and as DMSO solution for flexible use in experiments.
- CAS number 1380316-03-9; molecular weight 576.13 g·mol⁻¹.
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Medchemexpress LLC Midodrine hydrochloride | 43218-56-0 | 99.9% | 10 MG
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Midodrine hydrochloride is a selective and orally active adrenergic α1-receptor agonist. It strengthens vascular contraction and is utilized in research concerning cardiovascular diseases, such as orthostatic hypotension.
- Selective and orally active adrenergic α1-receptor agonist
- Strengthens vascular contraction
- Utilized in research for cardiovascular diseases like orthostatic hypotension
- Increases p-AMPK and PPARδ expression
- Increases Ca2+ in C2C12, HL1 and HepG2 cells
- Increases maximal mitochondrial oxidative phosphorylation and ATP content in C2C12 cells
- Reduces cellular lipid content in 3T3-L1 cells
- Reduces platelet-activating factor-induced death in mice
- Shows anti-hypotensive effects in orthostatic hypotension rat models
- Relieves hypertension in spontaneously hypertensive rat models
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Medchemexpress LLC Alectinib (Hydrochloride) | 1256589-74-8 | 99.9% | 100 MG
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Alectinib Hydrochloride is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner). It effectively inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively, and demonstrates effective central nervous system (CNS) penetration.
- Potent, selective, and orally available ALK inhibitor
- Effective central nervous system (CNS) penetration
- Molecular formula: C30H35ClN4O2
- Molecular weight: 519.08
- Appearance: White to off-white solid
- Recommended storage at 4°C, sealed and away from moisture
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000383859 GRP-60367 HYDROCHLO 10MM 1ML
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000370395 CP-809101 HYDROCHLO 25MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000370277 AP-III-A4 HYDROCHLO 25MG
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5000691748 LEONURINE HYDROCHLO 500MG
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5000701141 ALECTINIB HYDROCHLO 100MG
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5000693155 EPERISONE HYDROCHLO 10MG
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Medchemexpress LLC (S,S,S)-AHPC hydrochloride | 2115897-23-7 | 99.2% | 467.02 | C22H31ClN4O3S | 5MG
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(S,S,S)-AHPC hydrochloride is the hydrochloride salt of an AHPC-derived VHL ligand used as a building block and negative control in E3 ligase recruitment and PROTAC research. It facilitates the study of VHL-mediated ubiquitination and proteasomal degradation, and is supplied for synthetic and assay applications in small research quantities.
- High purity 99.2%
- Molecular weight 467.02
- Chemical formula C22H31ClN4O3S
- Solid white to yellow appearance
- Suitable as a negative control and VHL ligand building block for PROTAC design
- Available in small milligram pack sizes for research use
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