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Filtered Search Results
Medchemexpress LLC Endoxifen (hydrochloride) | 1197194-41-4 | 98.0% | 409.95 | 100 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Endoxifen hydrochloride is a key active metabolite of Tamoxifen with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. It has potential for breast cancer study.
- More potent ER antagonist than tamoxifen.
- Induces ER-alpha degradation and inhibits ER transcriptional activity.
- Targets estrogen receptor α for degradation in breast cancer cells, inhibiting proliferation.
- Exhibits strong growth inhibitory and cytotoxic effects on breast cancer cell lines at 10 μM.
- Rapidly absorbed and systemically available; leads to higher exposure levels than tamoxifen.
- Safe and effective in inhibiting human mammary tumor xenografts in female mice orally.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC SB-612111 hydrochloride | 99.6% | 454.86 | 50 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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SB-612111 hydrochloride is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki=0.33 nM). It exhibits selectivity for μ-, κ- and δ-receptors. It effectively antagonizes the pronociceptive action of Nociceptin in an acute pain model.
- Appearance: Solid
- Color: White to off-white
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: Powder: -20°C for 3 years, 4°C for 2 years. In solvent: -80°C for 6 months, -20°C for 1 month
- Solubility (In Vitro): DMSO: 15.62 mg/mL (34.34 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC EPZ011989 (hydrochloride) | 2095432-26-9 | 99.4% | 642.27 | 25 MG
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EPZ011989 hydrochloride is a potent and orally active Zeste Homolog 2 (EZH2) inhibitor. It demonstrates anti-tumor activity and functions as a click chemistry reagent. It is intended for research use only.
- Potent and orally active EZH2 inhibitor
- Ki value of <3 nM
- Shows anti-tumor activity
- Functions as a click chemistry reagent (contains an Alkyne group for CuAAc)
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC SRI-011381 hydrochloride | 2070014-88-7 | 99.6% | 365.94 g/mol | C20H32ClN3O | 1 G
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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SRI-011381 hydrochloride is a small-molecule, orally active agonist of the TGF-β/Smad signaling pathway with reported neuroprotective effects. Supplied as the hydrochloride salt for research use, the compound is characterized by a defined molecular weight and high reported purity suitable for in vitro and in vivo studies.
- Orally active TGF-β signaling agonist.
- Reported neuroprotective effects in preclinical studies.
- Supplied as the hydrochloride salt for improved handling and solubility.
- High reported purity (99.55%).
- Molecular weight 365.94 g/mol.
- For research use only.
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Medchemexpress LLC SGK1-IN-3 hydrochloride | 00-00-0 | 96.7% | C23H21Cl3N6O3S | 10MG
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SGK1-IN-3 hydrochloride is a research-grade small-molecule inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1), reported to inhibit SGK1 with an IC50 of <1 μM. Supplied as the hydrochloride salt, it is intended for biochemical and cell-based research applications, including studies of signaling pathways related to osteoarthritis.
- Potent SGK1 inhibition (IC50 <1 μM).
- Hydrochloride salt form for improved solubility.
- Suitable for biochemical and cell-based assays.
- High reported purity (~96.7%).
- Available in small research pack sizes for laboratory use.
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Medchemexpress LLC Bmt-090605 (hydrochloride) | 2231664-45-0 | 98.8% | 400.90 g·mol⁻¹ | C21H25ClN4O2 | 5 MG
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BMT-090605 hydrochloride is a potent, selective small-molecule inhibitor of adaptor protein-2 associated kinase 1 (AAK1) with additional activity against BIKE and GAK. Supplied as the hydrochloride salt for research use, it is provided as a solid with specified purity and storage recommendations, making it suitable for kinase profiling and target validation studies.
- Potent AAK1 inhibition with low-nanomolar IC50 (0.6 nM).
- Selective activity against related kinases BIKE and GAK.
- High purity (98.8%) suitable for biochemical assays.
- Molecular weight 400.90 g·mol⁻¹.
- Available in small pre-weighed sizes for research, including 5 mg.
- Stable as a powder when stored at recommended temperatures.
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Medchemexpress LLC Adrogolide hydrochloride | 166591-11-3 | 99.6% | 435.96 | C22H26ClNO4S | 25 MG
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Adrogolide hydrochloride is a research-grade prodrug converted rapidly in plasma to the dopamine D1 receptor agonist A-86929. Supplied as the hydrochloride salt, it is intended for laboratory research use only and is provided in pre-weighed quantities for assay preparation.
- High purity (≈99.6%) suitable for research applications.
- Molecular weight 435.96 and formula C22H26ClNO4S.
- Available in pre-weighed small quantities for in vitro and in vivo studies.
- Soluble in DMSO for assay preparation.
- Acts as a prodrug to the D1 receptor agonist A-86929.
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Medchemexpress LLC Cct241533 hydrochloride | 1431697-96-9 | 98.55% | 478.94 | 50 MG
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CCT241533 hydrochloride is a potent and selective CHK2 inhibitor with an IC50 of 3 nM and a Ki of 1.16 nM. It exhibits minimal cross-reactivity against a panel of kinases at 1 μM. X-ray crystallography confirms its binding to CHK2 in the ATP pocket. The compound blocks CHK2 activity in human tumor cell lines in response to DNA damage, significantly enhancing the cytotoxicity of two structurally distinct PARP inhibitors. Clear induction of the pS516 CHK2 signal by PARP inhibitor alone is abolished by CCT241533. The cytotoxicity (GI50) in HT-29, HeLa, and MCF-7 cells is 1.7, 2.2, and 5.1 μM, respectively.
- Potent and selective CHK2 inhibitor (IC50=3 nM)
- 63-fold selectivity over CHK1 (IC50=190 nM)
- Low hERG inhibition (IC50=22 μM)
- Blocks CHK2 activity in human tumor cell lines in response to DNA damage
- Enhances cytotoxicity of PARP inhibitors
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Medchemexpress LLC Olcegepant hydrochloride | 586368-06-1 | MFCD07772306 | 99.1% | 906.11 | C38H47Br2N9O5·HCl | 50 MG
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Olcegepant hydrochloride is a potent, selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor, provided as the hydrochloride salt for preclinical research use. The compound is supplied with reported high purity and is offered in multiple quantities and solution formats for laboratory studies.
- Potent, selective antagonist of the CGRP1 receptor.
- Reported high purity (~99.1%).
- Available in multiple sizes, including 5 mg-500 mg, and as DMSO solutions.
- Molecular formula C38H47Br2N9O5·HCl; molecular weight 906.11 g/mol.
- For research use only; not for human or clinical use.
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Medchemexpress LLC Lidocaine hydrochloride hydrate | 6108-05-0 | 99.8% | 100 MG
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Lidocaine hydrochloride hydrate inhibits sodium channels involving complex voltage and using dependence. It decreases growth, migration, and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. It is an amide derivative with potential for the research of ventricular arrhythmia.
- Inhibits sodium channels
- Decreases growth, migration, and invasion of gastric carcinoma cells
- Up-regulates miR-145 expression
- Inactivates MEK/ERK and NF-κB signaling pathways
- Potential for research of ventricular arrhythmia
- Causes completely reversible tail nerve block in rats
- Decreases cell proliferation in human gastric cancer cell line MKN45
- Inhibits MKN45 cell viability
- Increases apoptotic cell rate in MKN45 cells
- Down-regulates Cyclin D1 and up-regulates p21 expression
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Medchemexpress LLC Ssr180711 (hydrochloride) | 446031-79-4 | 99.9% | 361.66 | 100 MG
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SSR180711 hydrochloride is an orally active, selective, and reversible α7 acetylcholine nicotinic receptor (n-AChRs) partial agonist. It acts on rat α7 n-AChR (Ki=22 nM; IC50=30 nM) and human α7 n-AChR (Ki=14 nM; IC50=18 nM). This compound increases glutamatergic neurotransmission, ACh release, and long-term potentiation (LTP) in the hippocampus. It is intended for research use only.
- Orally active
- Selective and reversible α7 n-AChRs partial agonist
- Increases glutamatergic neurotransmission, ACh release, and long-term potentiation (LTP) in the hippocampus
- Selective for the α7 receptor subtype compared to α4β2, α3β2, α3β4, and α1β1γδ human n-AChR subtypes (IC50>5 μM)
- Rapidly penetrates into the brain (ID50=8 mg/kg; p.o.)
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Medchemexpress LLC Ninhydrin | 485-47-2 | 99.97% | 25 G
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Ninhydrin is a chromogenic analytical probe used for the quantification of amino acids and proteins. It reacts with primary and secondary amines, producing a characteristic blue or purple reaction product: diketohydrindylidene-diketohydrindamine. Most amino acids, with the exception of proline, can be hydrolyzed and subsequently quantified colorimetrically following chromatographic separation. This product, appearing as a white to light yellow solid, is intended for research use only and has not been fully validated for medical applications.
- Chromogenic analytical probe for the quantification of amino acids and proteins.
- Reacts with primary and secondary amines.
- Produces a blue or purple reaction product.
- Suitable for the colorimetric quantification of most amino acids after chromatographic separation.
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Medchemexpress LLC Caroverine hydrochloride | 55750-05-5 | MFCD01684929 | 98.9% | 401.93 g/mol | C22H28ClN3O2 | 5 MG
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Caroverine hydrochloride is a research reagent that acts as a potent, competitive, and reversible antagonist of NMDA and AMPA glutamate receptors. It also exhibits antioxidant and calcium-blocking activity with vasorelaxant effects, and is used in studies such as inner-ear tinnitus research. The compound is supplied as a white to off-white solid with high purity.
- Antagonist of NMDA and AMPA glutamate receptors.
- Exhibits antioxidant and calcium-blocking activity.
- Displays vasorelaxant effects useful in vascular studies.
- Suitable for research into inner-ear tinnitus mechanisms.
- High purity for research applications (98.9%).
- White to off-white solid, stable when stored sealed and protected from moisture.
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Medchemexpress LLC Etifoxine (hydrochloride) | 56776-32-0 | 99.8% | 337.24 | 100 MG
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Etifoxine hydrochloride is a non-benzodiazepine GABAergic compound that acts as a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. It exhibits anxiolytic and anticonvulsant properties in rodents. This product is intended for research and analytical applications.
- Positive allosteric modulator of GABAA receptors.
- Exhibits anxiolytic properties.
- Exhibits anticonvulsant properties.
- Intended for research and analytical applications.
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Medchemexpress LLC Claramine (hydrochloride) | 99.6% | 625.45 | 5 MG
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Claramine hydrochloride is a steroid polyamine with blood-brain barrier permeability. It can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and biological protein-based toxins.
- Steroid polyamine
- Blood-brain barrier permeability
- Regulates properties of lipid membranes
- Protects cells from various biological toxins, including misfolded protein oligomers and biological protein-based toxins
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